AB0023 DENDRITIC CELLS AS A PROMINENT MARKERS OF AUTOIMMUNE DISEASES

Background: Dendritic cells (DCs) are known to contribute the pathogenesis of different autoimmune diseases. It is clear nowadays role DCs in rheumatoid arthritis (RA) but not well investigated Axial spondylitis (AxSpA). a heterogeneous population and can be divided into groups: myeloid (mDCs) plasmacytoid (pDCs). induce both immune response tolerance. Objectives: To investigate subpopulations peripheral blood patients with early stage RA (duration illness up 12 months) AS. Methods: The study include sixty five forms diseases including 55 10 AxSpA. Diagnosis was established according ACR/EULAR criteria (2010). AxSpA ASAS criteria. All received conventional synthetic DMARDs. Thirty osteoarthritis (OA) used as control group. Analysis content B-lymphocytes, carried out by flow cytometry. subtypes were characterized following phenotypes: (CD3-CD14-CD19-HLA-DR + CD11c CD123-), CD11c-CD123 +), B-lymphocytes (CD19 +). Analyses performed before treatment after 3 6 months. Results: Patients significant evaluation comparison (25.3% vs 21.5, p=0.005). Furthermore, difference found number phenotype B-lymphocytes: 5.7% 3.1%, p = 0.0007). No differences observed plasmocytoid DCs. After month observation we detected reducing amount 26.7% 20.1% 16.4% respectively. Disease activity DAS28 droped low (4.32 to3.06, p=0.03). lower mDCs levels compared (19.3% 26.7, p=0.07). investigation decreasing 14.2%, p=0.05). percent pDCs constant did differ from level healthy donors. Conclusion: data obtained indicate that form rheumatic namely axial have common features such dominance their reduction disease. Disclosure Interests: None declared